Synthesis, Characterization and Antitrypanosomal Activity Of Metal Complexes Of 2-{(E)-[(4-Bromophenyl)imino]methyl}phenol

Authors

  • Uzair Khan Department of chemistry, Abdul Wali Khan University Mardan-23200 Khyber Pakhtunkhwa, Pakistan.
  • Sara Ali Department of Chemistry, Abdul Wali Khan University Mardan-23200, Khyber Pakhtunkhwa, Pakistan.
  • Zama Jan School of Physics, and Xi'an Key Laboratory of Sustainable Energy & Computational Materials Science, Xi'an Jiaotong University, Xi'an-710049, P. R. China. https://orcid.org/0009-0004-0153-401X
  • Muhammad Jamshed School of Chemistry, and Xi'an Key Laboratory of Sustainable Energy Materials Chemistry, Xi'an Jiaotong University, Xi'an-710049, P. R. China. https://orcid.org/0009-0008-8585-1942

DOI:

https://doi.org/10.56946/jce.v3i2.558

Keywords:

Schiff base metal complexes, structural characterization, anti-leishmanial activity, cytotoxicity

Abstract

The current study investigates the Antileishmanial and cytotoxic activity of synthesized Schiff base ligand 2-{(E)-[(4-bromophenyl)imino]methyl}phenol and their Metal complexes prepared by reflux process. Various metal salt is used in complexation like Zn, Cu, Ni, Co and the synthesized compounds is studied structurally with chromatographic technique and checked their solubility in THF, DMSO and CH3COCH3. Such compounds show good Anti-leishmanial activity with no Cytotoxicity which exhibited scarcer negative impacts and could serve as effective substances in Antileishmanial and Cytotoxicity.

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Published

2024-12-15
CITATION
DOI: 10.56946/jce.v3i2.558

How to Cite

Khan, U., Ali, S., Jan, Z., & Jamshed, M. (2024). Synthesis, Characterization and Antitrypanosomal Activity Of Metal Complexes Of 2-{(E)-[(4-Bromophenyl)imino]methyl}phenol. Journal of Chemistry and Environment, 3(2), 68–79. https://doi.org/10.56946/jce.v3i2.558

Issue

Vol. 3 No. 2 (2024)

Section

Article

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